Faculty Café with Dr. Kari Heckman: Modulating Macrophage-Mediated Inflammation for Good… or Bad?

Inflammation is a cause of good and bad for the body. Protection against pathogens involves a rapid inflammatory response and robust immune cell activity. However, even this protective mechanism can be so strong that its mediators threaten patients’ lives, as observed in some COVID-19 patients. This talk will clarify the positive and negative effects of inflammation and consider whether modulating the activity of the macrophage cell will yield better or worse outcomes in different contexts. Preliminary evidence of macrophage modulation will be presented to illustrate the potential effects of the phytochemical cardamonin on macrophage’s pro-inflammatory behavior.

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